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KMID : 1123920170310050277
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Korean Journal of Oriental Physiology and Pathology
2017 Volume.31 No. 5 p.277 ~ p.283
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Anti-allergic Effects of Jagamcho-tang in Ovalbumin-induced Atopic Dermatitis Mouse Model
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Noh Hyeon-Min
Park Sung-Gu
Kim Won-Jeong
Jo Eun-Hee
Ki Hyeon-Hui
Kim Dae-Ki
Park Min-Cheol
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Abstract
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Activated T helper 2 (Th2) immune function is hallmark of various allergic diseases. We investigated the anti-allergic effect of Jagamcho-tang extract(JE) on ovalbumin(OVA)-induced atopic dermatitis mice model and OVA-stimulated splenocytes isolated from the mice. Mice were intraperitoneally injected OVA/alum solution 2 times at interval of 14 days, followed by oral administration of JE for 7 days. After administration, mice were subcutaneously injected with OVA in ear. JE treatment reduced ear swelling and infiltration of inflammatory cells in ear. Serum levels of interleukin(IL)-4 and immunoglobulins, such as total-IgE and OVA-specific IgE, were decreased in JE treated group. Furthermore, JE treatment decreased OVA-induced Th2-associated cytokines like IL-4, IL-5 and IL-13 mRNA levels in splenocytes. In conclusion, JE reduced allergic immune response via IgE production and Th2 response in OVA-sensitized mice, suggesting that JE could be useful prescription for allergic diseases including atopic dermatitis.
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KEYWORD
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Jagamcho-tang(炙甘草湯), Atopic dermatitis, Allergy, T helper 2, Immunoglobulin E
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